What is Tranaxemic acid and where is it used?

Orally a drug used to stall bleeding and used in bleeding disorders, topical TXA is a skincare ingredient primarily used for pigmentation and discoloration. Largely data of TXA, orally and topical is particularly demonstrated in conditions such as melasma, by inhibiting the breakdown of fibrin which plays a role in melanin production. It has also been proposed for reddish marks post acne, to lighten dark spots, sun damage, and uneven skin tone caused by melanin overproduction. 

How does it work?

TXA inhibits the action of plasmin and plasminogen activator released by the skin cells, after UV radiation and thereby decreases their action on arachidonic acid, bFGF, Alpha MSH decreasing stimulation of the melanogenesis pathway. 

Is topical tranexamic acid safe for most skin types?

• Topical TXA is generally considered safe for most skin types, but it's advisable to perform a patch test before full application, for sensitive skin. 

How and when should I apply topical tranexamic acid?

• Maybe used once or twice daily, in combination with other ingredients or alone and with a broad-spectrum sunscreen. 

What are potential side effects?

• Mild irritation: May cause slight redness, dryness, or tingling at the application site, usually temporary. 

Can I use tranexamic acid with other skincare ingredients?

• Can be combined with most other skincare products like Silymarin, AHA’s and BHA’s, vitamin C, retinol, and hyaluronic acid, but consult a dermatologist if you have concerns. 

Who should not use topical tranexamic acid?

• While topical TXA is safe for most individuals, individuals with history of blood clotting issues, should consult their doctor before using TXA topically or orally.